Here it is....
Code: Select all
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\centering
\caption{\textbf{A list of the genes implicated in LQT syndrome including the accession number (NCBI), chromosomal location of the gene, the protein that is expressed, protein function, incidence of mutations \citep{Ackerman2005,Vohra2007} and the types of mutations found in patients \citep{Napolitano2010}.}}
\label{tab:list-of-genes}
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\toprule
LQT type & Gene name & Chromosome & Protein \& accession number & Protein function & Expression & AP phase & Incidence & Type of mutations and effects & Phenotypes\\
\midrule
LQT~1 & \textit{KCNQ1} (NM\_000218) & 11p15.5 & KvLQT1/Kv7.1 (NP\_000209) & I\textsubscript{Ks} $\alpha$-subunit & Heart, pancreas, kidney, lung, inner ear, placenta, intestine, liver, skin & 2 and 3 & 30 –- 35\% & Haploinsufficiency, dominant negative & RWS (Het)\\
LQT~2 & \textit{KCNH2} (NM\_000238) & 7q35 –- q36 & HERG/Kv11.1 (NP\_000229) & I\textsubscript{Kr} $\alpha$-subunit & Heart, brain, adrenal gland, thymus, lunch, muscle, intestine, liver & 3 & 30 –- 35\% & Haploinsufficiency, dominant negative, abnormal trafficking & RWS (Het), SIDS, SQT\\
LQT~3 & \textit{SCN5A} (NM\_198056) & 3p21 –- p24 & Nav1.5 (NP\_932173) & I\textsubscript{Na} $\alpha$-subunit & Heart, brain, eye, blood, ovary & 0 & 5 –- 10\% & Gain of function & RWS (Het) Brugada, SIDS, IVF, AV block (hom), SCD, SSS\\
LQT~4 & \textit{ANK2} (NM\_020977) & 4q25 –- q27 & Ankyrin-B (NP\_066187) & Anchor protein & Ubiquitous & & \textless1\% & Substution mutation & TdP, IVF, SCD\\
LQT~5 & \textit{KCNE1} (NM\_000219) & 21q22.1 –- q22.2 & MinK (NP\_000210) & I\textsubscript{Ks} $\beta$-subunit & Heart, brain, spleen, kidney, lunch, intestine, eye & 2 and 3 & \textless1\% & Substitution, insertion and deletion mutations & RWS (Het), JLNS (Hom), AV block\\
LQT~6 & \textit{KCNE2} (NM\_172201) & 21q22.1 & MiRP1 (NP\_751951) & I\textsubscript{Kr} $\beta$-subunit & Heart, stomach, brain & 3 & \textless1\% & Substitution, insertion and deletion mutations & RWS (Het), SIDS, AF\\
LQT~7 & \textit{KCNJ2} (NM\_000891) & 17q23.1 –- q24.2 & Kir2.1 (NP\_000882) & I\textsubscript{K1} & Heart, kidney, brain, eye, intestine, lung & 3 and 4 & Rare & Haploinsufficiency, dominant negative, gain of function & AF, ATS, SQT~3\\
LQT~8 & \textit{CACNAlc} (NM\_000719) & 12p13.3 & Cav1.2 (NP\_000710) & I\textsubscript{Ca} & Heart, brain, muscle, intestine, gonads, skin, stomach, lung & & Rare & Haploinsufficiency, dominant negative, abnormal trafficking & Timothy syndrome, BS~3\\
LQT~9 & \textit{Cav3} (NM\_033337) & 3p25 & Caveolin-3 (NP\_203123) & Scaffolding protein & Muscle, placenta, connective tissue, prostate & & Rare & Substitution mutation &\\
LQT~10 & \textit{SCN4B} (NM\_174934) & 11q23 & NaV$\beta$4 (NP\_777594) & I\textsubscript{Na} & Heart, brain, intestine, muscle, placenta, pancreas, eye, gonads & & Rare & Substitution mutation &\\
LQT~11 & \textit{AKAP9} (NM\_005751) & 7q21 -- q22 & A-kinase anchor protein (NP\_005742) & Anchor protein & Muscle, pancreas, heart, placenta, brain & & Rare & Substitution mutation &\\
LQT~12 & \textit{SNTA1} (NM\_003098) & 20q11.2 & Syntrophin (NP\_003089) & Peripheral membrane protein & Brain & & Rare & Substitution mutation &\\
\bottomrule
\end{tabular}}
\begin{tablenotes}[normal,flushleft]
RWS, Romano-Ward syndrome; JLNS, Jervell-Lange Neilson syndrome; het, heterozygote; hom, homozygote; SIDS, sudden infant death syndrome; SQT, short QT syndrome; IVF, idiopathic ventricular fibrillation; SCD, sudden cardiac death; SSS, sick sinus syndrome; TdP, Torsade de Pointes; AF, atrial fibrillation; ATS, Anderson-Tawil syndrome.
\end{tablenotes}
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Think I've got it hacked down enough. Okay, copy and paste killed the spacing of the stuff but it's all there.