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\documentclass[12pt,letterpaper]{article}
\usepackage[T1]{fontenc}
\usepackage{amsmath}
\begin{document}
\begin{align*}
A &= B \\ \\
&= C = D \\ \\
&= E = F,
\end{align*}
\end{document}
I'm sure that the solution should be trivial, but I really don't see it !

EDIT : I should probably use the alignat command, but it doesn't work right now...