You can choose the language used for a project in Project, Spelling...
But there's seems to be a problem with this setting since it is not taken into account by TeXnicCenter. I face the same problem (use of french and english)
Yes, you just have to create a project with your tex file. However it won't list the references that are in a bib file. If think you should have a look at Jabref which is a powerful bib file manager.